Which of the following are considered major risk factors for the development of preeclampsia?

Chronic hypertension is indeed a major risk factor for the development of preeclampsia because it creates an environment in which blood vessels are already under stress. In pregnant women, the presence of chronic hypertension can contribute to poor placentation and impaired vascular function, which are critical in the onset of preeclampsia. The elevated blood pressure can exacerbate the changes that occur during pregnancy, leading to increased risks for both the mother and the fetus.

Other significant risk factors for preeclampsia include a family history of the condition, smoking (though this is generally considered a risk factor for many negative health outcomes), and obesity. Each of these factors also contributes to the complex interplay of health issues that can lead to preeclampsia, but chronic hypertension stands out as a direct and recognized contributor to the condition’s development due to its impact on vascular health prior to and during pregnancy.