HELLO syndrome is diagnosed primarily by which clinical finding?

HELLO syndrome, which stands for Hemolysis, Elevated Liver enzymes, and Low Platelet count, is primarily diagnosed through the presence of thrombocytopenia, or low platelet count. This clinical finding is crucial because it indicates a disruption in the normal production of platelets, which can be a significant indicator of the syndrome.

In HELLO syndrome, thrombocytopenia occurs alongside other symptoms such as hemolysis and elevated liver enzymes, but the hallmark of the condition is the low platelet count. This triad of symptoms is critical for diagnosis and helps guide further management and treatment of the condition.

While high blood pressure, elevated liver enzymes, and severe abdominal pain can be associated findings, they are not the primary diagnostic criteria for HELLO syndrome. Thrombocytopenia stands out as the most significant laboratory finding that confirms the diagnosis of this syndrome.